中文簡介

《老化和發(fā)展機(jī)制》是一份多學(xué)科期刊，出版原創(chuàng)研究、理論和評論文章，旨在闡明包括人類在內(nèi)的生物系統(tǒng)老化和發(fā)展過程的基本機(jī)制。歡迎所有與上述有關(guān)的基礎(chǔ)研究領(lǐng)域的文章，但一般不接受那些描述年齡、發(fā)育和其他隨時間而變化的文章，而不提及它們的起源或?qū)ζ渌�結(jié)構(gòu)和功能水平的影響。臨床病例記錄和報告的心理和社會影響的生物過程的老化不屬于該雜志的范圍。隨著人類平均預(yù)期壽命的增加，老齡化和與年齡有關(guān)的疾病對我們社會的影響也在增加。老化研究現(xiàn)在是包括遺傳學(xué)、分子和細(xì)胞生物學(xué)、生物化學(xué)和行為領(lǐng)域的領(lǐng)導(dǎo)者在內(nèi)的數(shù)千個實(shí)驗(yàn)室的重點(diǎn)。老齡化研究綜述(ARR)涵蓋了這一領(lǐng)域的趨勢。它的目的是填補(bǔ)一個很大的空白，即一個來源的批判性評論和觀點(diǎn)的新發(fā)現(xiàn)的機(jī)制老化和年齡相關(guān)的疾病。在對控制細(xì)胞增殖、分化和存活機(jī)制的理解方面的快速進(jìn)展，正導(dǎo)致對衰老調(diào)控的新見解。從端粒酶到干細(xì)胞，再到能量和氧自由基代謝，這是衰老研究領(lǐng)域的一個令人興奮的新時代。正在確定延長壽命的操作的細(xì)胞和分子基礎(chǔ)，例如熱量限制，并正在開發(fā)預(yù)防與年齡有關(guān)的疾病的新方法。ARR出版的文章聚焦于從衰老研究的廣泛領(lǐng)域中選擇的主題，強(qiáng)調(diào)衰老過程的細(xì)胞和分子機(jī)制以及與年齡相關(guān)的疾病，如癌癥、心血管疾病、糖尿病和神經(jīng)退行性疾病。基礎(chǔ)老化研究在延長壽命和預(yù)防疾病方面的應(yīng)用也在本雜志中報道。

　　英文簡介

Mechanisms of Ageing and Development is a multidisciplinary journal for the publication of original research, theoretical and review articles, directed towards the illumination of the fundamental mechanisms underlying the process of ageing and development in biological systems, including man. Articles in all basic research areas relevant to the above are welcomed, but those describing age, developmental and other time-dependent changes without reference to their origins or effects on other levels of structure and function will not generally be accepted. Clinical case histories and reports on psychological and social influences on the biological processes of ageing do not fall within the scope of the journal. As the average human life expectancy has increased, so too has the impact of ageing and age-related disease on our society. Ageing research is now the focus of thousands of laboratories that include leaders in the areas of genetics, molecular and cellular biology, biochemistry, and behaviour. Ageing Research Reviews (ARR) covers the trends in this field. It is designed to fill a large void, namely, a source for critical reviews and viewpoints on emerging findings on mechanisms of ageing and age-related disease. Rapid advances in understanding of mechanisms that control cellular proliferation, differentiation and survival are leading to new insight into the regulation of ageing. From telomerase to stem cells to energy and oxyradical metabolism, this is an exciting new era in the multidisciplinary field of ageing research. The cellular and molecular underpinnings of manipulations that extend lifespan, such as caloric restriction, are being identified and novel approaches for preventing age-related diseases are being developed. ARR publishes articles on focussed topics selected from the broad field of ageing research, with an emphasis on cellular and molecular mechanisms of the ageing process and age-related diseases such as cancer, cardiovascular disease, diabetes and neurodegenerative disorders. Applications of basic ageing research to lifespan extension and disease prevention are also covered in this journal.

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