中文簡介

毒理學發(fā)表的研究文章與評估人類或動物接觸化學藥物、天然產(chǎn)品或合成材料可能對健康造成的不利影響有著廣泛的相關(guān)性。在毒理學的所有領(lǐng)域，無論是描述性的還是機械性的，以及解釋性的或理論性的調(diào)查中都發(fā)表了手稿，闡明了單獨或結(jié)合接觸有毒物質(zhì)的風險評估影響。研究可能涉及實驗動物或人類實驗對象，也可能側(cè)重于體外方法或?qū)嶒瀯游锸褂玫奶娲�方法。發(fā)表毒理研究的文章，這些毒理研究屬于結(jié)構(gòu)性生化或功能性研究，研究暴露代謝或物種的劑量路線對毒性反應(yīng)的影響，統(tǒng)計或基于機制的風險評估方法。毒物學的新方法。主要研究章節(jié)原始文章短通訊研討會摘要研討會或圓桌總結(jié)評論評論領(lǐng)域包括生化毒物學藥物動力學藥物動力學生殖和發(fā)育毒物學致癌免疫毒物學神經(jīng)毒物學肺毒物學實驗動物安全評價風險評估的替代方法。

　　英文簡介

Toxicological Sciences publishes research articles that are broadly relevant to assessing the potential adverse health effects resulting from exposure of human or animals to chemicals drugs natural products or synthetic materials. Manuscripts are published in all areas of toxicology both descriptive and mechanistic as well as interpretive or theoretical investigations that elucidate the risk assessment implications of exposure to toxic agents alone or in combination. Studies may involve experimental animals or human subjects or they may focus on in vitro methods or alternatives to the use of experimental animals. Presenting Articles on Toxicologic studies which are structural biochemical or functional in nature Investigations of the effects of dose route of exposure metabolism or species on toxic responses Statistical or mechanism-based approaches to risk assessment. New methods in toxicology. Featured Sections Original research articles short communications Symposium summaries Workshop or Roundtable summaries Reviews Commentaries Research Areas Include Biochemical toxicology pharmacokinetics pharmacodynamics Reproductive and developmental toxicology carcinogenesis Immunotoxicology neurotoxicology pulmonary toxicology In vitro methods alternatives to experimental animals Safety evaluation risk assessment.

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