中文簡介

《毒理學(xué)》是一本發(fā)表有關(guān)化學(xué)化合物（主要是對動物、組織或細(xì)胞，也包括對人）的生物效應(yīng)的原始科學(xué)論文的雜志。這些化合物包括工業(yè)化學(xué)品和殘留物、化學(xué)污染物、消費(fèi)品、藥物、金屬、農(nóng)藥、食品添加劑、化妝品和動物飼料添加劑。將優(yōu)先考慮調(diào)查有毒物質(zhì)的作用機(jī)制。將歡迎描述分子與細(xì)胞和遺傳過程相互作用的論文。將發(fā)表定量毒理學(xué)研究，這些研究與風(fēng)險(xiǎn)評估、暴露危險(xiǎn)的監(jiān)管管理和安全性評估有關(guān)。這尤其適用于致癌性、致突變性、胚胎毒性和相關(guān)領(lǐng)域，以及毒理學(xué)實(shí)驗(yàn)中動物使用的替代品。對人類具有毒理學(xué)意義的流行病學(xué)研究屬于該雜志的范圍。編輯們也歡迎就毒理學(xué)的當(dāng)前問題提交簡潔而有針對性的評論。免疫毒理學(xué)是該雜志的一個部分，它包括原始論文和同行評論，涉及化學(xué)物質(zhì)（包括藥物）對免疫系統(tǒng)的任何不良干擾：免疫抑制、超敏反應(yīng)、自身免疫、免疫介質(zhì)。藥物的副作用，免疫調(diào)節(jié)劑和免疫治療劑的毒性。環(huán)境與營養(yǎng)相互作用：一個新的領(lǐng)域，致力于對動物的原始研究和全面的批判性評論，以及對環(huán)境與營養(yǎng)相互作用的人類和計(jì)算機(jī)建模研究。其中包括環(huán)境變化對營養(yǎng)和食品生產(chǎn)的影響；識別營養(yǎng)與環(huán)境引起的疾病的相互作用；營養(yǎng)狀況對環(huán)境壓力反應(yīng)的影響；理解這種相互作用的機(jī)制及其對人類健康和福利的影響。即將出版的手稿列表可通過http://www.elsevier.nl/locate/toxicol-manipscripts在互聯(lián)網(wǎng)上查閱。

　　英文簡介

Toxicology is a journal for the publication of original scientific papers on the biological effects arising from the administration of chemical compounds, principally to animals, tissues or cells, but also to man. Such compounds include industrial chemicals and residues, chemical contaminants, consumer products, drugs, metals, pesticides, food additives, cosmetics, and additives to animal feedstuff. Preference will be given to investigations dealing with the mechanisms of action of toxic agents. Papers describing molecular interactions with cellular and genetic processes will be welcomed.Quantitative toxicological studies will be published that are of relevance to risk assessment and regulatory management of exposure hazards and safety evaluation. This applies particularly to carcinogenicity, mutagenicity, embryotoxicity and related areas, as well as to alternatives to the use of animals in toxicological experimentation. Epidemiological studies bearing toxicological significance to man fall within the scope of the journal. The Editors also welcome the submission of concise and pertinent reviews on current issues in toxicology.IMMUNOTOXICOLOGY, a section of the journal, includes original papers and peer reviews dealing with any adverse interference of chemicals, including drugs, with the immune system: immunosuppression, hypersensitivity, auto-immunity, immune-mediated side-effects of drugs, toxicity of immunomodulating and immunotherapeutic agents. ENVIRONMENTAL AND NUTRITIONAL INTERACTIONS: A new section dedicated to original research and comprehensive critical reviews of animal as well as human and computer modeling studies of the interactions between the environment and nutrition. These include the effects of environmental changes on nutrition and food production; identification of nutrient interactions with environmentally induced disorders; the effect of nutritional status on the response to environmental stresses; and understanding the mechanisms of such interactions and their impact on human health and welfare. A list of forthcoming manuscripts is available on Internet via http://www.elsevier.nl/locate/toxicol-manuscripts.

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