中文簡介

由生物醫學中心出版。ISSN:1742-2094。《神經炎癥雜志》是一份開放獲取、同行評議的在線雜志，關注中樞神經系統的先天免疫反應，包括小膠質細胞、星形膠質細胞、細胞因子、趨化因子和相關的分子過程。“神經炎癥”是對中樞神經系統的小膠質細胞和星形細胞反應和行為具有基本炎癥樣特征的一種概括，這些反應是多種神經系統疾病的發病機制和進展的核心。這個想法徹底改變了我們對阿爾茨海默氏癥的理解，它起源于阿爾茨海默氏癥，現在已經應用于其他神經退行性疾病，缺血性/毒性疾病，甚至是正常的大腦發育。神經炎癥包括一系列復雜的細胞反應，包括小膠質細胞和星形膠質細胞、細胞因子和趨化因子、補體蛋白、急性期蛋白、氧化損傷和相關的分子過程。神經炎癥是一個迅速發展的新領域，它徹底改變了我們對慢性神經疾病的認識。這一領域的研究人員已成長為涵蓋許多不同領域的背景，包括病理學、生物化學、分子生物學、遺傳學、臨床醫學和流行病學。這一領域的重要貢獻來自于對人群、患者、死后組織、動物模型和體外系統的研究。神經炎癥雜志將集中研究常見的致病過程，并為該領域的綜合評論提供一個論壇。

　　英文簡介

Published by BioMed Central. ISSN: 1742-2094.Journal of Neuroinflammation is an Open Access, peer-reviewed online journal that focuses on innate immunological responses of the central nervous system, involving microglia, astrocytes, cytokines, chemokines, and related molecular processes. 'Neuroinflammation' is an encapsulization of the idea that microglial and astrocytic responses and actions in the central nervous system have a fundamentally inflammation-like character, and that these responses are central to the pathogenesis and progression of a wide variety of neurological disorders. This idea has revolutionized our understanding of Alzheimer's disease, where it originated, and now has applications to other neurodegenerative diseases, to ischemic/toxic diseases, and even to normal brain development. Neuroinflammation incorporates a wide spectrum of complex cellular responses that include microglia and astrocytes, cytokines and chemokines, complement proteins, acute phase proteins, oxidative injury, and related molecular processes. Neuroinflammation is a new and rapidly expanding field that has revolutionized our understanding of chronic neurological diseases. This field has grown to encompass researchers with backgrounds in many diverse fields, including pathology, biochemistry, molecular biology, genetics, clinical medicine, and epidemiology. Important contributions to this field have come from work with populations, with patients, with postmortem tissues, with animal models, and with in vitro systems. The Journal of Neuroinflammation will bring together work focusing on common pathogenic processes, and provide a forum for integrative reviews and commentaries on this field.

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